Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits
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Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. / Andersen, Gitte; Rose, Christian Schack; Hamid, Yasmin Hassan; Drivsholm, Thomas; Borch-Johnsen, Knut; Hansen, Torben; Pedersen, Oluf.
I: Diabetes, Bind 52, Nr. 9, 01.09.2003, s. 2445-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits
AU - Andersen, Gitte
AU - Rose, Christian Schack
AU - Hamid, Yasmin Hassan
AU - Drivsholm, Thomas
AU - Borch-Johnsen, Knut
AU - Hansen, Torben
AU - Pedersen, Oluf
PY - 2003/9/1
Y1 - 2003/9/1
N2 - The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. The gene was examined in 61 Danish type 2 diabetic patients, and a total of six variants (-27C-->T, Ala206Thr, Ala272Ala, IVS2 + 10G-->A, IVS4 + 18T-->G, and IVS4 + 26G-->A) were identified and investigated in an association study, which included 503 type 2 diabetic patients and 510 glucose-tolerant control subjects. None of the variants were associated with type 2 diabetes. Interestingly, carriers of the codon 206 Thr allele had 18% lower fasting serum insulin levels (P = 0.002) and 20% lower insulinogenic index (P = 0.03) than homozygous carriers of the Ala allele. These results suggest that variation in the coding region of SLC2A10 does not contribute substantially to the pathogenesis of type 2 diabetes in the examined study population. However, the codon 206 polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels.
AB - The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. The gene was examined in 61 Danish type 2 diabetic patients, and a total of six variants (-27C-->T, Ala206Thr, Ala272Ala, IVS2 + 10G-->A, IVS4 + 18T-->G, and IVS4 + 26G-->A) were identified and investigated in an association study, which included 503 type 2 diabetic patients and 510 glucose-tolerant control subjects. None of the variants were associated with type 2 diabetes. Interestingly, carriers of the codon 206 Thr allele had 18% lower fasting serum insulin levels (P = 0.002) and 20% lower insulinogenic index (P = 0.03) than homozygous carriers of the Ala allele. These results suggest that variation in the coding region of SLC2A10 does not contribute substantially to the pathogenesis of type 2 diabetes in the examined study population. However, the codon 206 polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels.
KW - Aged
KW - Diabetes Mellitus, Type 2
KW - Female
KW - Gene Frequency
KW - Genetic Variation
KW - Genotype
KW - Glucose Transport Proteins, Facilitative
KW - Humans
KW - Male
KW - Middle Aged
KW - Monosaccharide Transport Proteins
KW - Phenotype
M3 - Journal article
C2 - 12941788
VL - 52
SP - 2445
EP - 2448
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 9
ER -
ID: 33030404