Adrenaline-induced mobilization of T cells in HIV-infected patients
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The present study aimed to investigate lymphocyte mobilization from peripheral cell reservoirs in HIV-infected patients. Nine HIV-infected patients on stable highly active anti-retroviral therapy (HAART), eight treatment-naive HIV-infected patients and eight HIV- controls received a 1-h adrenaline infusion. The adrenaline infusion induced a three-fold increase in the concentration of lymphocytes in all three groups. All HIV-infected patients mobilized significantly higher numbers of CD8+ cells but less CD4+ cells. All subjects mobilized CD45RA+CD62L+ and CD8+CD28+ cells to a lesser extent than CD45RO+CD45RA- and CD8+CD28-cells. Furthermore, high numbers of CD8+CD38+ cells were mobilized only in the HIV-infected patients. It was therefore predominantly T cells with an activated phenotype which were mobilized after adrenaline stimulation. It is concluded that the HIV-associated immune defect induced an impaired ability to mobilize immune-competent cells in response to stress stimuli. Furthermore, the study does not support the idea that CD4+ T cells are trapped in lymph nodes by HIV antigens, because untreated and HAART-treated HIV-infected patients mobilized similar numbers of CD4+ T cells. Finally, no evidence was found for the existence of a HAART-induced non-circulating pool of CD4+ T cells.
Original language | English |
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Journal | Clinical and Experimental Immunology |
Volume | 119 |
Issue number | 1 |
Pages (from-to) | 115-22 |
Number of pages | 8 |
ISSN | 0009-9104 |
Publication status | Published - Jan 2000 |
- ADP-ribosyl Cyclase, Adult, Anti-HIV Agents, Antigens, CD, Antigens, CD28, Antigens, CD38, Antigens, Differentiation, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Case-Control Studies, Epinephrine, Female, HIV Infections, Humans, Male, Membrane Glycoproteins, Middle Aged, NAD+ Nucleosidase, T-Lymphocyte Subsets, Journal Article, Research Support, Non-U.S. Gov't
Research areas
ID: 180572066