Drug-drug interactions between vitamin K antagonists and statins: a systematic review
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Accepted author manuscript, 273 KB, PDF document
Purpose: Concomitant use of vitamin K antagonists (VKA) and statins is frequent in cardiovascular patients. However, clinical guidelines on this drug combination are divergent. Therefore, we performed a systematic review to evaluate the effect of statin initiation on coagulation among VKA users. Methods: Following the PRISMA guidelines, we applied two broad search strategies for the drug interaction between VKA and statins in both Embase and Pubmed; 8623 unique hits were obtained. In the final sample, eight studies were included. Results: The most frequently used VKA in the studies was warfarin, while simvastatin was the most commonly initiated statin. All included studies showed a minor increase in the anticoagulant effect of VKA following statin initiation during VKA treatment. The reported increases in mean international normalized ratio (INR) ranged from 0.15–0.65. Conclusion: The anticoagulant effect of statin initiation in patients treated with VKA is likely to be of limited clinical relevance but should be evaluated individually.
Original language | English |
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Journal | European Journal of Clinical Pharmacology |
Volume | 77 |
Pages (from-to) | 1435–1441 |
Number of pages | 7 |
ISSN | 0031-6970 |
DOIs | |
Publication status | Published - 2021 |
- Anticoagulants, Drug interactions, Statins, Vitamin K antagonists, Warfarin
Research areas
ID: 261768980